Marble Burying Test Interpretation

Mice with ocd like symptoms tend to engage in a high degree of repetitive behaviors including digging.

Marble burying test interpretation.

Therefore the test serves largely as a measure. The marble burying test is commonly used to quantify anxiety obsessive compulsive or repetitive behaviour in rodents 1 3 performance on the marble burying test is also associated with general digging behaviour 4 7 and so the underlying construct being measured is still unclear regardless the typical protocol places 10 25 marbles in a cage containing sawdust or similar. When mice are placed in a novel cage a common response is to show increased digging behavior. The marble burying test measures one acute dose of anti anxiety agent for thirty minutes.

It is based on the observation that rats and mice will bury either harmful or harmless objects in their bedding. Marble burying is an animal model used in scientific research to depict anxiety or obsessive compulsive disorder ocd behavior. The marble burying task can be used both as an indicator of obsessive compulsive like ocd behavior and or anxiety like behavior. The marble burying test is used to record the number of marbles buried by mice placed in a novel environment.

There is also a genetic component to. It has also been proposed that the test may have predictive validity for the screening of novel antidepressants 12 15 anxiolytics 15 16 and antipsychotics 17 19. It can be weeks before a noticeable change is observed in patients. The marble burying test has been tested for the effects of the novelty of marbles by exposing animals to them in the home cage or administering the test repeatedly and neither has a pronounced effect on burying behaviour thomas et al 2009 njung e and handley 1991b homma and yamada 2009.

Marble burying the marble burying test is a useful model of neophobia 1 anxiety 1 7 and obsessive compulsive behavior 8 11. Rodent marble burying behavior in the marble burying test mbt is employed as a model or measure to study anxiety and compulsive like behaviors or anxiolytic and anticompulsive drug action. Regardless the test is widely applied to. However the test responds variably to a range of pharmacological interventions and little consensus exists regarding specific methodologies for its execution.

Mice which are placed individually in a cage bury glass marbles that are present in the cage. Rodent marble burying behavior in the marble burying test mbt is employed as a model or measure to study anxiety and compulsive like behaviors or anxiolytic and anticompulsive drug action. While widely used there is significant controversy over the interpretation of its results.